Longistatin in tick saliva blocks advanced glycation end-product receptor activation
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چکیده
منابع مشابه
Longistatin in tick saliva blocks advanced glycation end-product receptor activation.
Ticks are notorious hematophagous ectoparasites and vectors of many deadly pathogens. As an effective vector, ticks must break the strong barrier provided by the skin of their host during feeding, and their saliva contains a complex mixture of bioactive molecules that paralyze host defenses. The receptor for advanced glycation end products (RAGE) mediates immune cell activation at inflammatory ...
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Ticks are obligatory blood-sucking ectoparasites and while feeding for a single blood-meal, ticks remain attached to hosts by firmly embedding their barbed mouthparts for several days. Like mosquitoes, they cannot canulate an individual blood vessel; rather, they cause extensive damage in vascular beds and underlying tissues leading to the development of a blood pool, a feeding lesion of ticks....
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2014
ISSN: 0021-9738
DOI: 10.1172/jci74917